the invitation

Your life sucks! You always wished things could be different, and well one day a letter of beautiful detailing and penmanship arrives in the mail, it's the invitation that will literally change your life forever. That is,if you accept it.

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This topic is an Out Of Character part of the roleplay, ?the invitation?. Anything posted here will also show up there.

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Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.
This is the auto-generated OOC topic for the roleplay "the invitation"

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Himekura

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Choose A Vehicle From Sydney Auto Auctions - SponsorDirectory.com

Having no car of your own may make commuting harder, especially when your house is located not even close to the places you typically go to. Public transit is frequently reliable, but presently there are times when speed is required. There?s also occasions when you intend to go on road trips, off-the-beaten-path vacations, camping, and more. A car is unquestionably needed. Go to auto action company in sydney rather than setting up appointments with vehicle sellers.

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Mouse brain cells activated, reactivated in learning and memory

Dec. 12, 2012 ? Memories are made of this, the song says. Now neuroscientists have for the first time shown individual mouse brain cells being switched on during learning and later reactivated during memory recall. The results are published Dec. 13 in the journal Current Biology.

We store episodic memories about events in our lives in a part of a brain called the hippocampus, said Brian Wiltgen, now an assistant professor at the Center for Neuroscience and Department of Psychology at the University of California, Davis. (Most of the work was conducted while Wiltgen was working at the University of Virginia.) In animals, the hippocampus is important for navigation and storing memories about places.

"The exciting part is that we are now in a position to answer a fundamental question about memory," Wiltgen said. "It's been assumed for a long time that the hippocampus is essential for memory because it drives reactivation of neurons (nerve cells) in the cortex. The reason you can remember an event from your life is because the hippocampus is able to recreate the pattern of cortical activity that was there at the time."

According to this model, patients with damage to the hippocampus lose their memories because they can't recreate the activity in the cortex from when the memory was made. Wiltgen's mouse experiment makes it possible to test this model for the first time.

"We can now do a nice test of hippocampal function," Wiltgen said.

Current thinking is that learning activates a group of neurons that undergo changes, making new connections with each other to store the memory. Retrieving the memory reactivates the network.

Researchers working with human subjects, at UC Davis and elsewhere, use imaging techniques such as functional magnetic resonance imaging to see which areas of the brain are switched on and off in learning and retrieval. But fMRI cannot pick out an object as small as a single cell.

Wiltgen and University of Virginia graduate student Kaycie Tayler used a genetically modified mouse that carries a gene for a modified green fluorescent protein. When nerve cells in the mouse are activated, they produce a long-lived green fluorescence that persists for weeks, as well as a short-lived red fluorescence that decays in a few hours.

However, the whole system can be suppressed by dosing the mouse with the antibiotic doxycycline, so Tayler and Wiltgen could manipulate the point at which they started tagging activated cells.

The mice were put into a new cage with an unfamiliar odor and given a few minutes to explore. Then they were given a mild electrical shock through the cage floor. When returned to the cage a couple of days later, the mice would remember the shock and stay frozen in one place.

When they examined the brains of the mice, the researchers could see which cells had been activated initially to form the memory and which were reactivated later to recall it.

About 40 percent of the cells in the hippocampus that were tagged during initial memory formation were reactivated, Wiltgen said. There was also reactivation of cells in parts of the brain cortex associated with place learning and in the amygdala, which is important for emotional memory.

There was no evidence of reactivation when the mice were tested in a new environment that they did not remember, Wiltgen said.

The researchers also looked at whether reactivation changed as memories got older. Over several weeks, reactivation in the cortex and parts of the hippocampus remained stable, but it decreased in other brain regions like the amygdala.

In future work, Wiltgen's team plans to examine the role of the hippocampus and other brain regions in forming memories and explore new ways to activate or block memories.

Other authors of the paper are Kazumasa Tanaka at the University of Virginia and Leon Reijmers at Tufts University School of Medicine. The work was supported by the McKnight Foundation, the National Science Foundation and the Nakajima Foundation.

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Story Source:

The above story is reprinted from materials provided by University of California Davis (UCD).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Kaycie?K. Tayler, Kazumasa?Z. Tanaka, Leon?G. Reijmers, Brian?J. Wiltgen. Reactivation of Neural Ensembles during the Retrieval of Recent and Remote Memory. Current Biology, 2012; DOI: 10.1016/j.cub.2012.11.019

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/2eNVa1nrcAE/121213121345.htm

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Israel's Lieberman to face breach of trust charges: ministry

JERUSALEM (Reuters) - Israeli Foreign Minister Avigdor Lieberman will be indicted for fraud and breach of trust, charges that may lead him to resign, but the Justice Ministry dropped more serious corruption allegations in a nearly 12-year-old case.

The announcement comes just weeks before a January 22 election in which the right-wing party of Lieberman and Prime Minister Benjamin Netanyahu is predicted to win.

Lieberman has denied all wrongdoing and said in the past he would resign if indicted, though it was unclear how he would now act since the charges he face are less severe than anticipated.

Lieberman is expected to speak later on Thursday.

The fraud and breach of trust charges centered on suspected cronyism in Lieberman's efforts to promote an Israeli diplomat who had leaked him privileged information about a separate police probe pertaining to Lieberman.

Legal experts say Lieberman may resign, following the precedent of other Israeli officials indicted for corruption in recent years, including former prime minister Ehud Olmert, who was acquitted of most of those charges this year.

(Reporting by Ari Rabinovitch; Editing by Kevin Liffey)

Source: http://news.yahoo.com/israels-lieberman-face-breach-trust-charges-ministry-143556563.html

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Egypt court gives Christian 3 years for blasphemy

CAIRO (AP) ? A Cairo court on Wednesday convicted a Coptic Christian blogger who shared an anti-Islam film on social networking sites and sentenced him to three years in prison for blasphemy and contempt of religion.

The case of Alber Saber is one of several seen by rights advocates as a campaign led by Egypt's ultraconservative Islamists to curb free expression. Many of those targeted in the campaign are Christians, who make up about 10 percent of Egypt's population of 85 million.

Saber was arrested Sept. 13, after neighbors complained he had shared on Facebook the amateur film made in the United States that sparked protests across the Muslim world. His arrest came during a wave of public outrage over the film, produced by an Egyptian-American Copt.

At the time, an angry mob surrounded Saber's house, calling for his death and accusing him of heresy, atheism and of promoting the "Innocence of Muslims" ? the short film that portrays the Prophet Muhammad as a fraud, womanizer and buffoon.

Saber's verdict comes as Egypt has been plunged into a political crisis over a draft constitution. Islamist supporters say the charter is a step toward stability while critics warn it will open the door to increased suppression of freedom in the name of religion.

In announcing the verdict, the court in Cairo said Saber can be released on a bail pending his appeal.

Amnesty International condemned the verdict and said it considered Saber "a prisoner of conscience detained solely for peacefully exercising his right to freedom of expression." The London-based group also demanded Saber be freed immediately and that all charges against him be dropped.

"This is an outrageous verdict and sentence for a person whose only 'crime' was to post his opinions online," said Amnesty's Hassiba Hadj Sahraoui.

"The court should have thrown the case out on the first day, yet now he's been branded as having insulted religion," added Sahraoui, deputy chief of Amnesty's Middle East and North Africa program.

Last month, another Egyptian court convicted in absentia seven other Coptic Christians and a Florida-based American pastor, sentencing them to death on charges linked to the "Innocence of Muslims."

The charges were largely symbolic because the defendants, most of who live in the United States, are all outside Egypt and are thus unlikely to ever face the sentence. The man behind the anti-Islam film, Mark Basseley Youssef, was among those convicted. He was sentenced in a California court in November to one year in federal prison for probation violations in an unrelated matter.

Source: http://news.yahoo.com/egypt-court-gives-christian-3-years-blasphemy-173310288.html

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